News and Publications
Resources
Maternal insulin resistance causes oxidative stress and mitochondrial dysfunction in mouse oocytes
Hum Reprod. 2012 Jul;27(7):2130-45. Epub 2012 May 3. Ou XH, Li S, Wang ZB, Li M, Quan S, Xing F, Guo L, Chao SB, Chen Z, Liang XW, Hou Y, Schatten H, Sun QY.
May 03, 2012
The quest for human ovarian stem cells
Nature Medicine 18, 353–354 (2012). Epub 06 March 2012. Telfer E, Albertini D.
March 06, 2012
Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women
Nature Medicine 18, 413-421 (2012) . Epub 26 February 2012. White Y, Woods D, Takai Y, Ishihara O, Seki H, Tilly J
February 26, 2012
.gif)
Meiotic origins of maternal age-related aneuploidy
Biol Reprod. 2012 Jan 10;86(1):1-7. Print 2012 Jan. Chiang T, Schultz RM, Lampson MA.
January 10, 2012
Origins and rates of aneuploidy in human blastomeres
Fertil Steril. 2012 Feb;97(2):395-401. Epub 2011 Dec 21. Rabinowitz M, Ryan A, Gemelos G, Hill M, Baner J, Cinnioglu C, Banjevic M, Potter D, Petrov DA, Demko Z.
December 21, 2011
Conception to birth -- visualized
Alexander Tsiaras, Ted Talks. Uploaded by TEDtalksDirector on Nov 14, 2011 to www.youtube.com
November 14, 2011
Mitochondrial DNA content and 4977 bp deletion in unfertilized oocytes
Mol. Hum. Reprod. 2005 Dec.11(12): 843-846. Chan CCW, Liu V.W.S., Lau E.Y.L., Yeung W.S.B., Ng E.H.Y., Ho P.C.
November 09, 2011
The impact of obesity on egg quality
J Assist Reprod Genet. 2011 Jun;28(6):517-24. Epub 2011 May 28. Purcell SH, Moley KH.
May 28, 2011
The contribution of mitochondrial function to reproductive aging
J Assist Reprod Genet. 2011 Sep;28(9):773-83. Epub 2011 May 27. Bentov Y, Yavorska T, Esfandiari N, Jurisicova A, Casper RF.
May 27, 2011
The cytogenetics of polar bodies: insights into female meiosis and the diagnosis of aneuploidy
Mol Hum Reprod. 2011 Apr 14. Fragouli E, Alfarawati S, Goodall NN, Sánchez-García JF, Colls P, Wells D.
April 14, 2011
Mitochondrial dysfunction and apoptosis in cumulus cells of type I diabetic mice
PLoS One. 2010 Dec 28;5(12):e15901. Wang Q, Frolova AI, Purcell S, Adastra K, Schoeller E, Chi MM, Schedl T, Moley KH.
December 28, 2010
Validation of microarray comparative genomic hybridization for comprehensive chromosome analysis of embryos
Fertil Steril. 2011 Mar 1;95(3):953-8. Epub 2010 Oct 25. Gutiérrez-Mateo C, Colls P, Sánchez-García J, Escudero T, Prates R, Ketterson K, Wells D, Munné S.
October 25, 2010
Age related changes in mitochondrial function and new approaches to study redox regulation in mammalian oocytes in response to age or maturation conditions
Mitochondrion. 2011 Sep;11(5):783-96. Epub 2010 Sep 15. Eichenlaub-Ritter U, Wieczorek M, Lüke S, Seidel T.
September 15, 2010
Mitochondrial DNA transmission, replication and inheritance: a journey from the gamete through the embryo and into offspring and embryonic stem cells
Human Reproduction Update , Volume 16 (5): 488. Oxford University Press – Sep 1, 2010 St. John, Justin C.; Facucho-Oliveira, Joao; Jiang, Yan; Kelly, Richard; Salah, Rana
September 01, 2010
Oxidative stress and ATPase6 mutation is associated with primary ovarian insufficiency
Arch Gynecol Obstet. 2010 Sep;282(3):313-8. Epub 2010 Apr 2. Venkatesh S, Kumar M, Sharma A, Kriplani A, Ammini AC, Talwar P, Agarwal A, Dada R.
April 02, 2010
Mitochondrial DNA copy number, a marker of viability for oocytes
Biol Reprod. 2010 Jul;83(1):1-2. Epub 2010 Mar 10. Chiaratti MR, Meirelles FV.
March 10, 2010
The role of mitochondrial DNA copy number in mammalian fertility
Biol Reprod. 2010 Jul;83(1):52-62. Epub 2010 Feb 3. Wai T, Ao A, Zhang X, Cyr D, Dufort D, Shoubridge EA.
February 03, 2010
Preclinical validation of a microarray method for full molecular karyotyping of blastomeres in a 24-h protocol
Hum Reprod. 2010 April; 25(4): 1066–1075.
Published online 2010 January 24. Johnson D.S, Gemelos G, Baner J, Ryan A, Cinnioglu C, Banjevic M, Ross R, Alper M, Barrett B, Frederick J, Potter D, Behr B, Rabinowitz M
January 24, 2010
What next for preimplantation genetic screening? High mitotic chromosome instability rate provides the biological basis for the low success rate
Hum Reprod. 2009 November; 24(11): 2679–2682. Published online 2009 July 24. Vanneste, Evelyne; Voet, Thierry; Melotte, Cindy; Debrock, Sophie; Sermon, Karen; Staessen, Catherine; Liebaers, Inge; Fryns, Jean-Pierre; D'Hooghe, Thomas; Vermeesch Joris R.
July 24, 2009
Maternal diabetes causes mitochondrial dysfunction and meiotic defects in murine oocytes
Mol Endocrinol. 2009 Oct;23(10):1603-12. Epub 2009 Jul 2. Wang Q, Ratchford AM, Chi MM, Schoeller E, Frolova A, Schedl T, Moley KH.
July 02, 2009
The origin of human aneuploidy: where we have been, where we are going
Hum Mol Genet. 2007 Oct 15;16 Spec No. 2:R203-8. Hassold T, Hall H, Hunt P.
October 15, 2007
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival
Cell, 2007 Sep 21;130(6):1095-107. Yang H, Yang T, Baur JA, Perez E, Matsui T, Carmona JJ, Lamming DW, Souza-Pinto NC, Bohr VA, Rosenzweig A, de Cabo R, Sauve AA, Sinclair DA.
September 21, 2007
Mitochondria transfer can enhance the murine embryo development
J Assist Reprod Genet. 2007 Oct;24(10):445-9. Epub 2007 Aug 29. Yi YC, Chen MJ, Ho JY, Guu HF, Ho ES.
August 29, 2007
.gif)
Low mitochondrial DNA and ATP contents contribute to the absence of birefringent spindle imaged with PolScope in in vitro matured human oocytes
Hum Reprod. 2007 Jun;22(6):1681-6. Epub 2007 Apr 20. Zeng HT, Ren Z, Yeung WS, Shu YM, Xu YW, Zhuang GL, Liang XY.
April 20, 2007
mtDNA point mutations are present at various levels of heteroplasmy in human oocytes
Mol Hum Reprod. 2007 Mar;13(3):149-54. Epub 2007 Jan 26. Jacobs L, Gerards M, Chinnery P, Dumoulin J, de Coo I, Geraedts J, Smeets H.
January 26, 2007
.gif)
Regulated mitochondrial DNA replication during oocyte maturation is essential for successful porcine embryonic development
Biol Reprod. 2007 Feb;76(2):327-35. Epub 2006 Oct 11. Spikings EC, Alderson J, St John JC.
October 11, 2006
Correlation of abnormal mitochondrial distribution in mouse oocytes with reduced developmental competence.
Tohoku J Exp Med. 2006 Oct;210(2):137-44. Nagai S, Mabuchi T, Hirata S, Shoda T, Kasai T, Yokota S, Shitara H, Yonekawa H, Hoshi K.
October 01, 2006
Mitochondrial content reflects oocyte variability and fertilization outcome
Fertil Steril. 2006 Mar;85(3):584-91. Santos TA, El Shourbagy S, St John JC.
March 01, 2006
Mitochondria directly influence fertilisation outcome in the pig
Reproduction. 2006 Feb;131(2):233-45. El Shourbagy SH, Spikings EC, Freitas M, St John JC.
February 01, 2006
The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations
Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18769-70. Epub 2005 Dec 19. Loeb LA, Wallace DC, Martin GM.
December 27, 2005
Self-correction of chromosomally abnormal embryos in culture and implications for stem cell production
Fertil Steril. 2005 Nov;84(5):1328-34. Munné S, Velilla E, Colls P, Garcia Bermudez M, Vemuri MC, Steuerwald N, Garrisi J, Cohen J.
November 01, 2005
Oocyte Generation in Adult Mammalian Ovaries by Putative Germ Cells in Bone Marrow and Peripheral Blood
Cell, 2005 Jul 29;122(2):303-15. Johnson J, Bagley J, Skaznik-Wikiel M, Lee HJ, Adams GB, Niikura Y, Tschudy KS, Tilly JC, Cortes ML, Forkert R, Spitzer T, Iacomini J, Scadden DT, Tilly JL.
July 29, 2005
Role of oxidative stress in female reproduction
Reprod Biol Endocrinol. 2005; 3: 28.
Published online 2005 July 14. Agarwal A, Gupta S, Sharma R.
July 14, 2005
Microinjection of Cytoplasm or Mitochondria Derived from Somatic Cells Affects Parthenogenetic Development of Murine Oocytes
Biol Reprod. 2005 Jun;72(6):1397-404. Epub 2005 Feb 16. Takeda K, Tasai M, Iwamoto M, Onishi A, Tagami T, Nirasawa K, Hanada H, Pinkert CA.
June 01, 2005
Effect of female age on mouse oocyte developmental competence following mitochondrial injury
Biol Reprod. 2005 Aug;73(2):366-73. Epub 2005 Apr 20. Thouas GA, Trounson AO, Jones GM.
April 20, 2005
Low oocyte mitochondrial DNA content in ovarian insufficiency
Hum Reprod. 2005 Mar;20(3):593-7. Epub 2004 Dec 17. May-Panloup P, Chrétien MF, Jacques C, Vasseur C, Malthièry Y, Reynier P.
March 01, 2005
Mitochondrial dysfunction in mouse oocytes results in preimplantation embryo arrest in vitro
Biol Reprod. 2004 Dec;71(6):1936-42. Epub 2004 Jul 30. Thouas GA, Trounson AO, Wolvetang EJ, Jones GM.
December 01, 2004
Oocyte mitochondria: strategies to improve embryogenesis
Hum Cell. 2004 Dec;17(4):195-201. Nagai S, Mabuchi T, Hirata S, Shoda T, Kasai T, Yokota S, Shitara H, Yonekawa H, Hoshi K.
December 01, 2004
Mitochondria in human oogenesis and preimplantation embryogenesis: engines of metabolism, ionic regulation and developmental competence
Reproduction. 2004 Sep;128(3):269-80. Van Blerkom J.
September 01, 2004
Germline stem cells and follicular renewal in the postnatal mammalian ovary
Nature 428, 2004 Mar 11;428(6979):145-50. Johnson J, Canning J, Kaneko T, Pru JK, Tilly JL.
March 11, 2004
Comparison of mitochondrial DNA contents in human embryos with good or poor morphology at the 8-cell stage
Fertil Steril. 2004 Jan;81(1):73-9. Lin DP, Huang CC, Wu HM, Cheng TC, Chen CI, Lee MS.
January 01, 2004
Oxidative stress, mitochondrial DNA mutation, and impairment of antioxidant enzymes in aging
Exp Biol Med (Maywood). 2002 Oct;227(9):671-82. Wei YH, Lee HC.
October 01, 2002
Altered meiotic regulation in oocytes from diabetic mice
Biol Reprod. 2002 Jul;67(1):220-31. Colton SA, Pieper GM, Downs SM.
February 04, 2002
Involvement of mitochondria in oxidative stress-induced cell death in mouse zygotes
Biol Reprod. 2000 Jun;62(6):1745-53. Liu L, Trimarchi JR, Keefe DL.
June 01, 2000
Birth after the injection of sperm and the cytoplasm of tripronucleate zygotes into metaphase ii oocytes in patients with repeated implantation failure after assisted fertilization procedures
Fertil Steril. 1999 Oct;72(4):702-6. Huang CC, Cheng TC, Chang HH, Chang CC, Chen CI, Liu J, Lee MS.
October 01, 1999
Mitochondrial transfer between oocytes: potential applications of mitochondrial donation and the issue of heteroplasmy
Hum Reprod, 1998 Oct; 13 (10):2857-68. Van Blerkom J, Sinclair J, Davis P.
October 01, 1998